TIME 4 GH-REM Ingredient Profile By Brian Batcheldor BSC
GH-REM – Active Ingredients Profile
Glycine: Several clinical studies have demonstrated that Glycine administration is a reliable promoter of a “clear and significant” rise in serum Growth Hormone levels. In sleep studies, Glycine ingestion before bedtime impressively improved subjective sleep quality.
Arginine, Ornithine and Lysine: It is almost common knowledge that Arginine has the ability to elevate Growth Hormone when administered orally. However, the dosage ranges are pretty specific and efficacy is achieved at the lower end of the scale, as stomach upset will also accompany higher dosages and thus negates any advantage. Whilst the addition of Lysine has reliably been demonstrated to potentiate the effect of lower dose Arginine, complexation with Ornithine has yielded a highly beneficial targeted response to high intensity resistance training: elevated Growth Hormone and IGF-1 along with reduced IGF Binding Protein 3 during recovery.
Taurine: Normal Taurine levels are known to support an optimal circadian rhythm, the sleep-wake cycle. Taurine depletion is a common scenario in many athletes, but this can often occur through our own doing. Beta Alanine supplementation has been hailed as one of the greatest supplemental protocols for improving recovery/delaying the onset of fatigue. As such, this amino acid has become a mainstay in most Pre-Workout formulas, but there are no free rides. Increasing Beta Alanine levels is a sure fire way to deplete Taurine, -fact. Recent studies indicate that Taurine is required for normal mitochondrial protein synthesis and normal electron transport chain activity; it is known that defects in these events can lead to severe mitochondrial oxidative stress and a host of potentially serious repercussions.
L-Theanine: Identified by numerous studies as a safe natural sleep aid, this amino acid promotes relaxation without drowsiness. Unlike conventional sleep inducers, L-Theanine is not a sedative but promotes good quality of sleep through anxiolysis, -inhibition of anxiety. It is believed to achieve this through up-regulation of inhibitory neurotransmitters and possible modulation of Serotonin and Dopamine in selected areas. It has also recently been shown to increase levels of brain-derived neurotrophic factor.
5-Hydroxytryptophan and vitamin B6: Given orally, 5-HTP easily crosses the blood-brain barrier and effectively increases central nervous system synthesis of Serotonin, -a neurotransmitter that helps regulate sleep patterns. Vitamin B6, Pyridoxine, is key to this whole process; it is involved in the conversion of a small amount of the Tryptophan in your body to Niacin, or Vitamin B-3, and Serotonin.
Valerian Root Extract: A cornerstone of most natural sleep formulas, Valerian’s reliability here is backed up by numerous studies. The key to efficacy is high Valerenic Acid content, as this is a powerful modulator of GABBA receptors.
Chamomile Extract: Supported by studies over decades and the last major one being only published December 2017, Chamomile Extract has been proven to significantly improve sleep quality across various demographics. There is common ground here with its effectiveness in treating anxiety, that being a proven interaction with the benzodiazepine receptor.
Magnesium Aspartate: Magnesium in its various salts has demonstrated a clear ability to target sleep disorders, with improved subjective measures of insomnia, sleep efficiency, sleep time and sleep onset latency, early morning awakening. Likewise, insomnia objective measures such as concentration of Serum Renin, Melatonin and Cortisol, reduced blood pressure and improved sleep were noted from supplementation. Magnesium Aspartate has excellent bioavailability and is thus a predictable way to elevate magnesium levels to those used in studies.
Potassium Citrate: Potassium levels are known to support optimal circadian rhythm status, along with promote regular heartbeat and muscle relaxation to encourage sleep.
Zinc Citrate: Zinc deficiency is known to impact Growth Hormone levels, supplementation also demonstrates elevation of IGF-1. However, it is as part of any effective natural sleep formula it has been most used.
Choline: Supplementation of this has lead to decreased anxiety and improved sleep, possibly through mechanisms involving the hippocampus.
Vitamin D3: It would be fair to say that most people in the northern hemisphere suffer a shortage of Vitamin D, which is most certainly linked to poor sleep quality, increased stress, cardiovascular disease and growth disruption. Moderate to high dose D3 has reliably been indicated to elevate Growth Hormone levels by over 30% in healthy individuals.
Black Pepper (Piperine): Black Pepper contains an active component called Piperine which is able to modify supplement and drug metabolism. In clinical trials Piperine has been shown to increase the bioavailability of several nutrients and herbs through increased absorption. It has also been shown to boost fat metabolism through thermogenesis.
MCT: MCT stands for Medium Chain Triglycerides and is comprised of primarily caprylic and capric fatty acids which is derived from Coconut Oil. They are a form of saturated fatty acids and have numerous health benefits ranging from improved cognitive function to better weight management. Consuming clean fats before bedtime will give you a steady stream of energy that prevents blood sugar swings which will improve sleep quality and decrease the chances of waking due to low blood sugar. MCT’s are converted to Ketones which is used by the brain as fuel. MCT’s can also help to burn body fat whilst you sleep.
Vitamin C: Best known as an antioxidant, but it also works with various enzymes in the body. In relation to Growth Hormone (GH), Vitamin C acts as a co-factor in the activity of an enzyme called Peptidylglycine Alpha-Amidating Monooxygenase, or PAM, which activates various neuropeptides, or brain proteins. PAM exists in large amounts in both the hypothalamus of the brain, where Growth-Hormone-Releasing Hormone (GHRH) is produced, and the pituitary gland, where GH is produced. The thought is that vitamin C, through its actions on PAM, activates Growth-Hormone-Releasing Hormone from the hypothalamus, which then triggers the release of GH from the pituitary gland.