What is AstraGin ®
WHAT IS ASTRAGIN?
FOUNDATION FOR HEALTHY GUT FUNCTIONS
The human gut has a huge impact on the entire health of the body. A healthy gut contributes to better absorption, a healthy gut ecosystem, stronger immune functions, heart health, brain health, improved mood, healthy sleep, and more.
Nutrients in the foods, once digested, may enter the human body from the gut lumen by passive diffusion and osmosis. But many nutrients such as amino acids, do require active transporters located on the intestinal epithelial cell membrane to transport them from the gut lumen to circulation, such as SGLT1 for glucose absorption. These active transporters are activated by mRNA.
Disruption of normal barrier function is a fundamental factor in inflammatory bowel disease, which includes increased epithelial cell death, modified mucus configuration, altered tight junctions, along with decreased expression of antimicrobial peptides.
Gut microbiota is a dynamic “organ” of critical importance for human health. In healthy conditions the symbiotic microorganisms in the intestinal tract participate in the normal nutrient metabolism and immunity regulation of the host. Gut mucosal integrity is absolutely important for the adhesion and growth of gut microbiota.
The lymphoid elements of the gut comprise organized lymphoid tissues such as the Peyer’s patches (PP), and the mesentric lymph nodes (MLN). The effector sites of the intestine are the mucosal epithelium and underlying lamina propria (LP). Here there are many different immune cells including activated T cells, plasma cells, mast cells, dendritic cells and macrophages. Inflamed intestinal epithelial cell and lamina propria reduce these immune cells and weaken the immune functions.
For more details, please view the scientific papers
WHAT IS ASTRAGIN? – ASTRAGIN® PROMOTES ABSORPTION, INTESTINAL WALL REGENERATION, MICROBIOTA POPULATION
AND IMMUNE FUNCTIONS
AstraGin® is NuLiv Science’s proprietary gut nutraceutical composed of highly purified and fractionated Panax notoginseng and Astragalus membranaceus produced by a proprietary pharmaceutical extraction and processing technology.
AstraGin® has shown in 16 in-vitro and 8 in-vivo studies that are published in the Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research and Scientific Reports to:
- increase the absorption of peptides, amino acids, fatty acids, vitamins and phytonutrients by up-regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4.
- repair ulcerated and damaged intestinal walls and reduce intestinal submucosa inflammation. AstraGin® was shown in a hematoxylin-eosin stain and a MPO assay to reduce ulceration and unclear surfaces of intestinal epithelial cells and sub-mucosal edema in TNBS-induced colitis rats.
- may help maintain a healthy microbiota population by mending ulcerated and damaged intestinal epithelial cell surfaces for the microbiota to populate.
- may help support stronger immune functions by mending ulcerated epithelial cells and reducing the inflammation in intestinal mucosal lamina propria that hosts the gut-associated lymphoid tissue (GALT1), T cells, plasma cells , mast cells, dendritic cells, and macrophages.
For details, please view the scientific papers
WHAT IS ASTRAGIN? – ASTRAGIN® INCREASES ABSORPTION & BIOAVAILABILITY OF AMINO ACIDS, PEPTIDES, FATTY ACIDS, VITAMIN, AND PHYTONUTRIENTS
Many nutrients, such as glucose and amino acids, are absorbed through special absorption sites on intestinal lumen by special transport proteins.
AstraGin® has shown in 16 in-vitro in Caco-2 cell and 8 in-vivo in normal and TNBS-induced colitis rat to increase the absorption of amino acids, peptides, fatty acids, folate, and phtyo nutrients by up-regulating the expression level of special mRNA and transport proteins, such as SGLT1 and CAT1.