Citrulline MalateĀ is a non-essential amino acid. It plays an essential in the urea cycle, which rids the body of harmful compounds. Citrulline can also help to dilate blood vessels to increase blood flow, increase the post-exercise increase in growth hormone, and may play a role in muscle building. Citrulline Malate is Citrulline + Malic acid. The acid from Citrulline Malate helps the body to produce cellular energy. Shortage of Malic Acid in the body is associated with chronic fatigue.