10) Amino Acids (2019) 51:691–704

The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial

Tom Cliford1  · Matthew Ventress2  · Dean M. Allerton2  · Sarah Stansfeld2  · Jonathan C. Y. Tang3,4 · William D. Fraser3,4 · Barbara Vanhoecke4  · Janne Prawitt4  · Emma Stevenson1


This study examined whether consuming collagen peptides (CP) before and after strenuous exercise alters markers of muscle damage, inflammation and bone turnover. Using a double-blind, independent group’s design, 24 recreationally active males consumed either 20 g day−1 of CP or a placebo control (CON) for 7 days before and 2 days after performing 150 drop jumps. Maximal isometric voluntary contractions, countermovement jumps (CMJ), muscle soreness (200 mm visual analogue scale), pressure pain threshold, Brief Assessment of Mood Adapted (BAM+) and a range of blood markers associated with muscle damage, inflammation and bone turnover C-terminal telopeptide of type 1 collagen (β-CTX) and N-terminal pro-peptides of type 1 pro-collagen (P1NP) were measured before supplementation (baseline; BL), pre, post, 1.5, 24 and 48 h post-exercise. Muscle soreness was not significantly different in CP and CON (P=0.071) but a large effect size was evident at 48 h postexercise, indicative of lower soreness in the CP group (90.42±45.33 mm vs. CON 125.67±36.50 mm; ES=2.64). CMJ height recovered quicker with CP than CON at 48 h (P=0.050; CP 89.96±12.85 vs. CON 78.67±14.41% of baseline values; ES=0.55). There were no statistically significant effects for the other dependent variables (P>0.05). β-CTX and P1NP were unaffected by CP supplementation (P>0.05). In conclusion, CP had moderate benefits for the recovery of CMJ and muscle soreness but had no influence on inflammation and bone collagen synthesis.